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GENE - TERM ANNOTATION REPORT

RGD ID: 736838
Species: Mus musculus
RGD Object: Gene
Symbol: Tyms
Name: thymidylate synthase
Acc ID: DOID:9008443
Term: Colorectal Neoplasms
Definition: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
Definition Source(s): MESH:D015179
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tyms ISOTyms (Rattus norvegicus)5133433RGDmRNA, protein:increased expression, increased activity:adenocarcinoma (rat) 
Tyms ISOTYMS (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanismPMID:15222106 PMID:15386371 PMID:15500737 PMID:16141798 PMID:16943523 PMID:17047489 PMID:17943475 PMID:18607850 PMID:18676755 PMID:19020767 PMID:25944804
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