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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736832
Species: Homo sapiens
RGD Object: Gene
Symbol: EGF
Name: epidermal growth factor
Acc ID: CHEBI:8069
Term: phenobarbital
Definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Chemical ID: MESH:D010634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
EGFmultiple interactionsEXP 6480464CTDPhenobarbital inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Phenobarbital inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein]PMID:25625231 PMID:30364229
EGFmultiple interactionsISOEgf (Mus musculus)6480464CTDPhenobarbital inhibits the reaction [EGF protein binds to EGFR protein]PMID:6309801
EGFmultiple interactionsISOEgf (Rattus norvegicus)6480464CTDEGF protein inhibits the reaction [Phenobarbital results in increased expression of CYP2B1 mRNA]; Phenobarbital inhibits the reaction [EGF protein binds to EGFR protein]; Phenobarbital promotes the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Phenobarbital promotes the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]PMID:10828207 PMID:11377398 PMID:14722249 PMID:27427493
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