GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | EGF | multiple interactions | EXP | | 6480464 | CTD | RTKI cpd inhibits the reaction [EGF protein affects the localization of FOXO3 protein]; RTKI cpd inhibits the reaction [EGF protein results in decreased expression of and results in decreased secretion of KLK3 protein]; RTKI cpd inhibits the reaction [EGF protein results in decreased expression of AR protein]; RTKI cpd inhibits the reaction [EGF protein results in increased abundance of Calcium]; RTKI cpd inhibits the reaction [EGF protein results in increased activity of STAT3 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased expression of CCNB1 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased expression of CCNE1 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased expression of CDK1 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased expression of CDK2 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased expression of FOS protein]; RTKI cpd inhibits the reaction [EGF protein results in increased expression of GPER1 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of SRC protein]; RTKI cpd inhibits the reaction [EGF protein results in increased secretion of MMP1 protein]; RTKI cpd inhibits the reaction [Estradiol promotes the reaction [EGF protein results in increased phosphorylation of EGFR protein]]; RTKI cpd promotes the reaction [Amiodarone inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]] | PMID:11309286 PMID:11527950 PMID:16472761 PMID:17656145 PMID:19749156 PMID:21185374 PMID:25841994 PMID:25856345 PMID:25969534 PMID:26385184 PMID:26470790 PMID:26515726 PMID:28974440 PMID:36430902 | EGF | multiple interactions | ISO | Egf (Mus musculus) | 6480464 | CTD | RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of MAPK7 protein] | PMID:14737115 | EGF | multiple interactions | ISO | Egf (Rattus norvegicus) | 6480464 | CTD | RTKI cpd inhibits the reaction [EGF protein results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased susceptibility to Desoxycorticosterone] | PMID:10516208 PMID:11751714 PMID:15849355 | | ||||||||||||||||||||||
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