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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736829
Species: Homo sapiens
RGD Object: Gene
Symbol: SHH
Name: sonic hedgehog signaling molecule
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SHHdecreases expressionEXP 6480464CTDProgesterone results in decreased expression of SHH mRNAPMID:20660070
SHHmultiple interactionsEXP 6480464CTD4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of SHH mRNA]; [Estradiol co-treated with Progesterone] results in decreased expression of SHH mRNA; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of SHH mRNA]; U 0126 promotes the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of SHH mRNA]PMID:20660070
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