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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736829
Species: Homo sapiens
RGD Object: Gene
Symbol: SHH
Name: sonic hedgehog signaling molecule
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SHHincreases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of SHH mRNAPMID:35811015
SHHmultiple interactionsEXP 6480464CTDS-(1,2-dichlorovinyl)cysteine inhibits the reaction [Lipopolysaccharides results in increased expression of SHH mRNA]PMID:35811015
SHHdecreases expressionISOShh (Rattus norvegicus)6480464CTDLipopolysaccharides results in decreased expression of SHH mRNAPMID:21110116
SHHdecreases expressionISOShh (Mus musculus)6480464CTDLipopolysaccharides results in decreased expression of SHH mRNAPMID:12057914
SHHmultiple interactionsISOShh (Rattus norvegicus)6480464CTDcyclopamine inhibits the reaction [SHH protein inhibits the reaction [Lipopolysaccharides results in decreased expression of and results in decreased localization of GLI1 protein]]; cyclopamine inhibits the reaction [SHH protein inhibits the reaction [Lipopolysaccharides results in decreased expression of PTCH1 mRNA]]; SHH protein inhibits the reaction [Lipopolysaccharides results in decreased expression of and results in decreased localization of GLI1 protein]; SHH protein inhibits the reaction [Lipopolysaccharides results in decreased expression of PTCH1 mRNA]; SHH protein inhibits the reaction [Lipopolysaccharides results in decreased expression of PTCH1 protein]PMID:21110116
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