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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736829
Species: Homo sapiens
RGD Object: Gene
Symbol: SHH
Name: sonic hedgehog signaling molecule
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SHHdecreases expressionEXP 6480464CTDQuercetin results in decreased expression of SHH mRNAPMID:33070227
SHHmultiple interactionsEXP 6480464CTD[SHH protein co-treated with Quercetin] results in increased expression of GLI1 protein; SHH protein inhibits the reaction [Quercetin results in decreased expression of ACTA2 protein]; SHH protein inhibits the reaction [Quercetin results in decreased expression of CDH2 protein]; SHH protein inhibits the reaction [Quercetin results in decreased expression of GLI2 protein]; SHH protein inhibits the reaction [Quercetin results in decreased expression of SMO protein]; SHH protein inhibits the reaction [Quercetin results in decreased expression of SNAI1 protein]; SHH protein inhibits the reaction [Quercetin results in decreased expression of TGFB1 protein]; SHH protein inhibits the reaction [Quercetin results in decreased expression of VIM protein]; SHH protein inhibits the reaction [Quercetin results in decreased phosphorylation of SMAD2 protein]; SHH protein inhibits the reaction [Quercetin results in decreased phosphorylation of SMAD3 protein]; SHH protein inhibits the reaction [Quercetin results in increased expression of CDH1 protein]; SHH protein inhibits the reaction [Quercetin results in increased expression of PTCH1 protein]PMID:33070227
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