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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736819
Species: Homo sapiens
RGD Object: Gene
Symbol: ID1
Name: inhibitor of DNA binding 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ID1decreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of ID1 mRNAPMID:20106945
ID1increases expressionEXP 6480464CTDBenzo(a)pyrene metabolite results in increased expression of ID1 mRNA; Benzo(a)pyrene results in increased expression of ID1 mRNAPMID:16269432 PMID:24356939 PMID:32234424
ID1decreases expressionISOId1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of ID1 mRNAPMID:27195522
ID1increases expressionISOId1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of ID1 mRNAPMID:21569818 PMID:22228805 PMID:32417428
ID1multiple interactionsISOId1 (Mus musculus)6480464CTD[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of ID1 mRNA; AHR protein affects the reaction [Benzo(a)pyrene affects the expression of ID1 mRNA]PMID:22228805 PMID:27858113
ID1multiple interactionsISOId1 (Rattus norvegicus)6480464CTD[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of ID1 mRNA; [Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of ID1 mRNA; [Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of ID1 mRNA; [Benzo(a)pyrene co-treated with fluoranthene] affects the expression of ID1 mRNAPMID:18711122
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