GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | DRD2 | affects binding | EXP | | 6480464 | CTD | Spiperone binds to DRD2 protein | PMID:20969853 PMID:21999579 PMID:8804920 | DRD2 | multiple interactions | EXP | | 6480464 | CTD | Melitten inhibits the reaction [Spiperone binds to DRD2 protein] | PMID:20969853 | DRD2 | affects binding | ISO | Drd2 (Mus musculus) | 6480464 | CTD | Spiperone binds to DRD2 protein | PMID:11226678 PMID:2833825 | DRD2 | affects binding | ISO | Drd2 (Rattus norvegicus) | 6480464 | CTD | Spiperone binds to DRD2 protein | PMID:11927170 PMID:14559291 PMID:16137708 PMID:16889759 PMID:18457824 PMID:1975278 PMID:2018630 PMID:25522657 PMID:6149133 PMID:8804920 PMID:8829135 | DRD2 | multiple interactions | ISO | Drd2 (Mus musculus) | 6480464 | CTD | amitraz inhibits the reaction [Spiperone binds to DRD2 protein]; demethylchlordimeform inhibits the reaction [Spiperone binds to DRD2 protein]; NR3C1 protein promotes the reaction [Spiperone binds to DRD2 protein] | PMID:11226678 PMID:2833825 | DRD2 | multiple interactions | ISO | Drd2 (Rattus norvegicus) | 6480464 | CTD | 8-fluoro-12-(4-methylpiperazin-1-yl)-6H-(1)benzothieno(2,3-b)(1,5)benzodiazepine inhibits the reaction [Spiperone binds to DRD2 protein]; Amphetamine inhibits the reaction [Spiperone binds to DRD2 protein]; Caffeine inhibits the reaction [N-Methyl-3,4-methylenedioxyamphetamine promotes the reaction [Spiperone binds to DRD2 protein]]; Cocaine affects the reaction [Spiperone binds to DRD2 protein]; Haloperidol inhibits the reaction [Spiperone binds to DRD2 protein]; manganese chloride inhibits the reaction [DRD2 protein binds to Spiperone]; N-Methyl-3,4-methylenedioxyamphetamine promotes the reaction [Spiperone binds to DRD2 protein]; perospirone inhibits the reaction [Spiperone binds to DRD2 protein]; Pilocarpine inhibits the reaction [Spiperone binds to DRD2 protein]; Pilocarpine promotes the reaction [Spiperone binds to DRD2 protein]; Remoxipride inhibits the reaction [Spiperone binds to DRD2 protein]; Spiperone inhibits the reaction [Cocaine promotes the reaction [[DRD2 protein results in increased phosphorylation of TH protein] which results in increased abundance of Dopamine]] | PMID:11927170 PMID:14559291 PMID:16137708 PMID:16889759 PMID:17161392 PMID:1975278 PMID:2018630 PMID:20729865 PMID:21484877 PMID:6149133 | |
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