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GENE - TERM ANNOTATION REPORT

RGD ID: 736778
Species: Mus musculus
RGD Object: Gene
Symbol: Grm5
Name: glutamate receptor, metabotropic 5
Acc ID: GO:0007216
Term: G protein-coupled glutamate receptor signaling pathway
Definition: A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Ends with regulation of a downstream cellular process, e.g. transcription.
Definition Source(s): GOC:mah, GOC:signaling, PMID:9131252
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 IBAFB:FBgn0019985, PANTHER:PTN001173581, RGD:2742, RGD:2746, UniProtKB:O15303, UniProtKB:P41594, UniProtKB:Q132552290270GO_Central (PMID:21873635)

PMID:21873635
 ISORGD:27462290270RGD GO_REF:0000096, MGI:MGI:4417868
 ISOUniProtKB:P415942290270MGI GO_REF:0000096, MGI:MGI:4834177
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.