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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736778
Species: Mus musculus
RGD Object: Gene
Symbol: Grm5
Name: glutamate receptor, metabotropic 5
Acc ID: CHEBI:29474
Term: (S)-3,5-dihydroxyphenylglycine
Definition: A glycine derivative that is L-alpha-phenylglycine substituted at positions 3 and 5 on the phenyl ring by hydroxy groups.
Chemical ID: MESH:C079215
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Grm5increases activityISOGrm5 (Rattus norvegicus)6480464CTD3,5-dihydroxyphenylglycine results in increased activity of GRM5 proteinPMID:17179862
Grm5multiple interactionsISOGrm5 (Rattus norvegicus)6480464CTD6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM5 protein]; [3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide binds to GRM5 protein] promotes the reaction [3,5-dihydroxyphenylglycine binds to and results in increased activity of GRM5 protein]PMID:15608073 PMID:17179862
Grm5multiple interactionsISOGRM5 (Homo sapiens)6480464CTD[3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide binds to GRM5 protein] promotes the reaction [3,5-dihydroxyphenylglycine binds to and results in increased activity of GRM5 protein]PMID:15608073
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