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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736778
Species: Mus musculus
RGD Object: Gene
Symbol: Grm5
Name: glutamate receptor, metabotropic 5
Acc ID: CHEBI:18243
Term: dopamine
Definition: Catechol in which the hydrogen at position 4 is substituted by a 2-aminoethyl group.
Chemical ID: MESH:D004298
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:27466480464CTD[6-methyl-2-(phenylethynyl)pyridine binds to and results in decreased activity of GRM5 protein] inhibits the reaction [Methamphetamine results in decreased abundance of Dopamine], [6-methyl-2-(phenylethynyl)pyridine binds to and results in decreased activity of GRM5 protein] inhibits the reaction [Methamphetamine results in increased secretion of Dopamine], [6-methyl-2-(phenylethynyl)pyridine binds to and results in decreased activity of GRM5 protein] inhibits the reaction [Veratridine results in increased secretion of Dopamine], [6-methyl-2-(phenylethynyl)pyridine binds to and results in decreased activity of GRM5 protein] which results in decreased secretion of Dopamine

PMID:12907309
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.