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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736773
Species: Mus musculus
RGD Object: Gene
Symbol: Slc1a2
Name: solute carrier family 1 (glial high affinity glutamate transporter), member 2
Acc ID: CHEBI:64215
Term: 2,3-dimethoxynaphthalene-1,4-dione
Definition: A naphthoquinone that is 1,4-naphthoquinone bearing two methoxy substituents at positions 2 and 3. Redox-cycling agent that induces intracellular superoxide anion formation and, depending on the concentration, induces cell proliferation, apoptosis or necrosis. Used to study the role of ROS in cell toxicity, apoptosis, and necrosis.
Chemical ID: MESH:C063002
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc1a2decreases expressionISOSLC1A2 (Homo sapiens)6480464CTD2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of SLC1A2 mRNAPMID:17547211
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