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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736765
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP1B1
Name: cytochrome P450 family 1 subfamily B member 1
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP1B1decreases activityEXP 6480464CTDProgesterone results in decreased activity of CYP1B1 proteinPMID:33814510
CYP1B1decreases expressionEXP 6480464CTDProgesterone results in decreased expression of CYP1B1 mRNAPMID:18037150
CYP1B1multiple interactionsEXP 6480464CTD[Estradiol co-treated with Progesterone] results in increased expression of CYP1B1 mRNA; Progesterone promotes the reaction [laquinimod metabolite results in increased expression of CYP1B1 mRNA]PMID:20660070 PMID:32668270
CYP1B1decreases expressionISOCyp1b1 (Rattus norvegicus)6480464CTDProgesterone results in decreased expression of CYP1B1 proteinPMID:8674863
CYP1B1increases expressionISOCyp1b1 (Rattus norvegicus)6480464CTDProgesterone results in increased expression of CYP1B1 mRNAPMID:20726854
CYP1B1multiple interactionsISOCyp1b1 (Rattus norvegicus)6480464CTD[Estradiol co-treated with Progesterone co-treated with Hydrocortisone co-treated with PRL protein] inhibits the reaction [benz(a)anthracene results in increased expression of CYP1B1 protein]; Progesterone inhibits the reaction [benz(a)anthracene results in increased expression of CYP1B1 protein]; Progesterone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]PMID:32668270 PMID:8674863
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