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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736649
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP8B1
Name: cytochrome P450 family 8 subfamily B member 1
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP8B1increases expressionISOCyp8b1 (Rattus norvegicus)6480464CTDStreptozocin results in increased expression of CYP8B1 mRNA; Streptozocin results in increased expression of CYP8B1 proteinPMID:10393316 PMID:25905778
CYP8B1multiple interactionsISOCyp8b1 (Rattus norvegicus)6480464CTD[resveratrol co-treated with Streptozocin] results in decreased expression of CYP8B1 mRNA; INS1 protein inhibits the reaction [Streptozocin results in increased expression of CYP8B1 mRNA]; Streptozocin inhibits the reaction [resveratrol results in increased expression of CYP8B1 mRNA]PMID:10393316 PMID:25905778
CYP8B1multiple interactionsISOCyp8b1 (Mus musculus)6480464CTD[Dietary Fats co-treated with Streptozocin] results in decreased expression of CYP8B1 mRNAPMID:29382564
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