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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736649
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP8B1
Name: cytochrome P450 family 8 subfamily B member 1
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP8B1increases expressionISOCyp8b1 (Mus musculus)6480464CTDEthanol results in increased expression of CYP8B1 mRNAPMID:19167417 PMID:23894352 PMID:28095641
CYP8B1multiple interactionsISOCyp8b1 (Rattus norvegicus)6480464CTD1,3,7,9-tetramethyluric acid inhibits the reaction [[Dietary Fats co-treated with Ethanol co-treated with Carbon Tetrachloride] results in increased expression of CYP8B1 protein]; [Dietary Fats co-treated with Ethanol co-treated with Carbon Tetrachloride] results in increased expression of CYP8B1 proteinPMID:35872049
CYP8B1multiple interactionsISOCyp8b1 (Mus musculus)6480464CTDAM 251 inhibits the reaction [Ethanol results in increased expression of CYP8B1 mRNA]; BTG2 protein affects the reaction [Ethanol results in increased expression of CYP8B1 mRNA]; Melatonin inhibits the reaction [Ethanol results in increased expression of CYP8B1 mRNA]; YY1 protein affects the reaction [Ethanol results in increased expression of CYP8B1 mRNA]PMID:23894352 PMID:28095641
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