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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736627
Species: Homo sapiens
RGD Object: Gene
Symbol: FN1
Name: fibronectin 1
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FN1increases expressionEXP 6480464CTDParaquat results in increased expression of FN1 proteinPMID:29495171 PMID:30419666 PMID:35817254
FN1multiple interactionsEXP 6480464CTDHPGD protein inhibits the reaction [Paraquat results in increased expression of FN1 protein]; THBS1 protein affects the reaction [Paraquat results in increased expression of FN1 protein]PMID:30419666 PMID:35817254
FN1decreases expressionISOFn1 (Mus musculus)6480464CTDParaquat results in decreased expression of FN1 mRNAPMID:16797015
FN1increases expressionISOFn1 (Mus musculus)6480464CTDParaquat results in increased expression of FN1 mRNA; Paraquat results in increased expression of FN1 proteinPMID:17215068 PMID:26345256 PMID:35817254
FN1increases expressionISOFn1 (Rattus norvegicus)6480464CTDParaquat results in increased expression of FN1 mRNA; Paraquat results in increased expression of FN1 proteinPMID:23803522 PMID:25873302 PMID:30317802
FN1multiple interactionsISOFn1 (Rattus norvegicus)6480464CTDprolinedithiocarbamate inhibits the reaction [Paraquat results in increased expression of FN1 mRNA]PMID:23803522
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