GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | IFNB1 | increases expression | EXP | | 6480464 | CTD | Poly I-C results in increased expression of IFNB1 mRNA; Poly I-C results in increased expression of IFNB1 protein | PMID:17669408 PMID:18779317 PMID:21418039 PMID:22558189 PMID:28572013 PMID:31154625 PMID:32244040 PMID:35817128 PMID:36958387 | IFNB1 | increases secretion | EXP | | 6480464 | CTD | Poly I-C results in increased secretion of IFNB1 protein | PMID:22558189 PMID:31154625 | IFNB1 | multiple interactions | EXP | | 6480464 | CTD | [Dronabinol co-treated with Cannabidiol] inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; [Vehicle Emissions analog co-treated with Poly I-C] results in increased expression of IFNB1 mRNA; Cannabidiol inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; Dronabinol inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; IRF7 protein affects the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; IRF7 protein mutant form affects the reaction [Nicotine inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]]; IRF7 protein mutant form inhibits the reaction [Nicotine inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein]]; IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein]; Nicotine inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; Nicotine inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein]; Smoke inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; TLR3 protein affects the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; TP53 protein affects the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; Wortmannin inhibits the reaction [[Vehicle Emissions analog co-treated with Poly I-C] results in increased expression of IFNB1 mRNA] | PMID:16399790 PMID:18779317 PMID:28572013 PMID:31154625 PMID:32244040 PMID:35817128 | IFNB1 | increases expression | ISO | Ifnb1 (Mus musculus) | 6480464 | CTD | Poly I-C results in increased expression of IFNB1 mRNA | PMID:16116226 PMID:18323514 PMID:19426678 PMID:22546503 PMID:25780039 PMID:30726814 PMID:36958387 | IFNB1 | increases expression | ISO | Ifnb1 (Rattus norvegicus) | 6480464 | CTD | Poly I-C results in increased expression of IFNB1 mRNA | PMID:24423102 PMID:28726298 | IFNB1 | increases secretion | ISO | Ifnb1 (Mus musculus) | 6480464 | CTD | Poly I-C results in increased secretion of IFNB1 protein | PMID:24600036 PMID:30726814 | IFNB1 | multiple interactions | ISO | Ifnb1 (Mus musculus) | 6480464 | CTD | apilimod inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein]; APPL1 protein promotes the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; BX795 inhibits the reaction [Poly I-C results in increased expression of IFNB1 protein]; Luteolin inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; pitavastatin inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; Pravastatin inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; Progesterone inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; Resveratrol inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; sodium arsenite inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; sodium arsenite inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein]; Sodium Selenite inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; trametinib promotes the reaction [Poly I-C results in increased expression of IFNB1 mRNA] | PMID:16116226 PMID:18279804 PMID:18323514 PMID:19426678 PMID:22546503 PMID:24600036 PMID:25780039 PMID:30726814 | IFNB1 | multiple interactions | ISO | Ifnb1 (Rattus norvegicus) | 6480464 | CTD | MIR26A mRNA inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA] | PMID:24423102 | | ||||||||||||||||||||||
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