GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | IFNB1 | increases expression | ISO | Ifnb1 (Mus musculus) | 40902812 | RGD | lipopolysaccharide increases expression of IFNb1 mRNA in macrophages | | IFNB1 | increases expression | EXP | | 6480464 | CTD | Lipopolysaccharides results in increased expression of IFNB1 mRNA; Lipopolysaccharides results in increased expression of IFNB1 protein | PMID:26861016 PMID:27385120 PMID:32244040 PMID:35811015 | IFNB1 | multiple interactions | EXP | | 6480464 | CTD | [Dronabinol co-treated with Cannabidiol] inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 protein]; [S-(1,2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in increased expression of IFNB1 mRNA; Cannabidiol inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 protein]; Dronabinol inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 protein]; oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; S-(1,2-dichlorovinyl)cysteine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA] | PMID:26861016 PMID:32244040 PMID:35811015 | IFNB1 | decreases expression | ISO | Ifnb1 (Mus musculus) | 6480464 | CTD | Lipopolysaccharides results in decreased expression of IFNB1 mRNA | PMID:12057914 | IFNB1 | increases expression | ISO | Ifnb1 (Mus musculus) | 6480464 | CTD | Lipopolysaccharides results in increased expression of IFNB1 mRNA; Lipopolysaccharides results in increased expression of IFNB1 protein | PMID:14644621 PMID:15907790 PMID:16291660 PMID:17920563 PMID:18177342 PMID:18323514 PMID:19426678 PMID:19627980 PMID:20023007 PMID:20861358 PMID:21586572 PMID:23106696 PMID:24056979 PMID:25780039 PMID:30053449 PMID:30726814 PMID:33285210 | IFNB1 | increases expression | ISO | Ifnb1 (Rattus norvegicus) | 6480464 | CTD | Lipopolysaccharides results in increased expression of IFNB1 mRNA | PMID:20861358 | IFNB1 | increases secretion | ISO | Ifnb1 (Mus musculus) | 6480464 | CTD | Lipopolysaccharides results in increased secretion of IFNB1 protein | PMID:30726814 PMID:31350693 | IFNB1 | multiple interactions | ISO | Ifnb1 (Mus musculus) | 6480464 | CTD | 4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; 4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 protein]; 4-octylphenol inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; [IFNB1 protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide; [Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased expression of IFNB1 mRNA; [Lipopolysaccharides results in increased activity of TLR4 protein] which results in increased expression of IFNB1 mRNA; [resiquimod co-treated with Lipopolysaccharides] results in increased expression of IFNB1 mRNA; ADIPOQ protein inhibits the reaction [[Lipopolysaccharides results in increased activity of TLR4 protein] which results in increased expression of IFNB1 mRNA]; ADIPOR1 protein promotes the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]]; ADIPOR2 protein promotes the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]]; alachlor inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; alachlor inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 protein]; apigenin-6,8-di-C-glycopyranoside inhibits the reaction [Lipopolysaccharides results in increased secretion of IFNB1 protein]; APPL1 protein promotes the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; Arsenic Trioxide inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; Arsenic Trioxide inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 protein]; Atrazine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; Benomyl inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; bisphenol A inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 protein]; chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; Chlordecone inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; cinnamaldehyde inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; cirsimarin inhibits the reaction [Lipopolysaccharides results in increased secretion of IFNB1 mRNA]; cobaltiprotoporphyrin inhibits the reaction [Ethanol promotes the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]]; cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in increased secretion of IFNB1 protein]; deoxynivalenol promotes the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; Dexamethasone inhibits the reaction [[IFNB1 protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]; Dicofol inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; diethyl phthalate inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; Ethanol inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; ethyl N-allyl-N-(2-methyl-3-(4-(4-amidinophenoxycarbonyl)phenyl)propenoyl)aminoacetate methanesulfonate inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; HMOX1 protein inhibits the reaction [[Lipopolysaccharides results in increased activity of TLR4 protein] which results in increased expression of IFNB1 mRNA]; HMOX1 protein inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; HMOX1 protein promotes the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]]; IFNB1 protein affects the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; IFNB1 protein affects the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; IFNB1 protein affects the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; IFNB1 protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]; Lipopolysaccharides inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; Luteolin inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; Malathion inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; MAPKAPK2 protein affects the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; MAPKAPK3 protein affects the reaction [MAPKAPK2 protein affects the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]]; Methoxychlor inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; methyldithiocarbamate promotes the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; nonylphenol inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; octachlorostyrene inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; Pentachlorophenol inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; pitavastatin inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; Pravastatin inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; Quercetin inhibits the reaction [[IFNB1 protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]; Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; scolymoside inhibits the reaction [Lipopolysaccharides results in increased secretion of IFNB1 protein]; Simazine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; sodium arsenite inhibits the reaction [Lipopolysaccharides results in increased secretion of IFNB1 protein]; Sodium Selenite inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; tocotrienol, delta inhibits the reaction [[IFNB1 protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]; trametinib promotes the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; zinc protoporphyrin inhibits the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]]; Ziram inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA] | PMID:14644621 PMID:15851485 PMID:15907790 PMID:16116226 PMID:17920563 PMID:18177342 PMID:18279804 PMID:18323514 PMID:19426678 PMID:19627980 PMID:20023007 PMID:20861358 PMID:21586572 PMID:22185406 PMID:23106696 PMID:24056979 PMID:25780039 PMID:30053449 PMID:30726814 PMID:31350693 PMID:33285210 | IFNB1 | multiple interactions | ISO | Ifnb1 (Rattus norvegicus) | 6480464 | CTD | ADIPOQ protein inhibits the reaction [Ethanol promotes the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]]; ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; Ethanol promotes the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA] | PMID:20861358 | | ||||||||||||||||||||||
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