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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736587
Species: Mus musculus
RGD Object: Gene
Symbol: Scd1
Name: stearoyl-Coenzyme A desaturase 1
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Scd1decreases expressionISOScd (Rattus norvegicus)6480464CTDDiethylnitrosamine results in decreased expression of SCD1 mRNAPMID:20360939
Scd1multiple interactionsISOScd (Rattus norvegicus)6480464CTD[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of SCD1 mRNA; [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of SCD1 mRNA; caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in decreased expression of SCD1 mRNA]PMID:20360939 PMID:22129741 PMID:28943392
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