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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736559
Species: Homo sapiens
RGD Object: Gene
Symbol: ESR1
Name: estrogen receptor 1
Acc ID: CHEBI:50131
Term: 5-aza-2'-deoxycytidine
Definition: A 2'-deoxyribonucleoside that has formula C8H12N4O4.
Chemical ID: MESH:C014347
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ESR1decreases expressionEXP 6480464CTDDecitabine results in decreased expression of ESR1 mRNA; Decitabine results in decreased expression of ESR1 proteinPMID:17891453 PMID:19027819
ESR1decreases methylationEXP 6480464CTDDecitabine results in decreased methylation of ESR1 promoterPMID:34534549
ESR1decreases stabilityEXP 6480464CTDDecitabine results in decreased stability of ESR1 mRNAPMID:17891453
ESR1increases expressionEXP 6480464CTDDecitabine results in increased expression of ESR1 mRNAPMID:18701604 PMID:19458056 PMID:21515334
ESR1multiple interactionsEXP 6480464CTD[Decitabine co-treated with TFAP2C protein] results in increased expression of ESR1 mRNA; [Decitabine co-treated with trichostatin A] affects the expression of ESR1 mRNA; [Decitabine co-treated with trichostatin A] promotes the reaction [TFAP2C protein binds to ESR1 promoter]; [Decitabine co-treated with trichostatin A] promotes the reaction [TFAP2C protein results in increased expression of ESR1 mRNA]; [Decitabine co-treated with trichostatin A] results in decreased expression of ESR1 mRNA; [Decitabine co-treated with trichostatin A] results in decreased expression of ESR1 protein; [Decitabine co-treated with trichostatin A] results in decreased stability of ESR1 mRNA; [Decitabine co-treated with trichostatin A] results in increased expression of ESR1 mRNA; Decitabine promotes the reaction [trichostatin A results in increased expression of ESR1 mRNA]; TFAP2C protein promotes the reaction [[Decitabine co-treated with trichostatin A] results in increased expression of ESR1 mRNA]PMID:17533736 PMID:17891453 PMID:18092350 PMID:18264725 PMID:19458056
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