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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736559
Species: Homo sapiens
RGD Object: Gene
Symbol: ESR1
Name: estrogen receptor 1
Acc ID: CHEBI:34687
Term: dibutyl phthalate
Definition: A phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol. Although used extensively as a plasticiser, it is a ubiquitous environmental contaminant that poses a risk to humans.
Chemical ID: MESH:D003993
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ESR1affects bindingEXP 6480464CTDDibutyl Phthalate analog binds to ESR1 protein; Dibutyl Phthalate binds to ESR1 proteinPMID:15464722 PMID:19913605 PMID:20822795
ESR1decreases methylationEXP 6480464CTDDibutyl Phthalate results in decreased methylation of ESR1 promoterPMID:16326419
ESR1increases activityEXP 6480464CTDDibutyl Phthalate results in increased activity of ESR1 proteinPMID:28571686
ESR1multiple interactionsEXP 6480464CTDDibutyl Phthalate binds to and results in increased activity of ESR1 protein; Dibutyl Phthalate inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [Dibutyl Phthalate binds to and results in increased activity of ESR1 protein]PMID:15840436 PMID:27633901 PMID:28571686 PMID:29162470 PMID:33049310
ESR1affects bindingISOEsr1 (Mus musculus)6480464CTDDibutyl Phthalate binds to ESR1 proteinPMID:19913605
ESR1increases activityISOEsr1 (Rattus norvegicus)6480464CTDDibutyl Phthalate results in increased activity of ESR1 proteinPMID:19643168
ESR1increases expressionISOEsr1 (Rattus norvegicus)6480464CTDDibutyl Phthalate results in increased expression of ESR1 mRNA; Dibutyl Phthalate results in increased expression of ESR1 proteinPMID:24067674
ESR1multiple interactionsISOEsr1 (Mus musculus)6480464CTD[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diethyl phthalate co-treated with di-n-octyl phthalate co-treated with diisodecyl phthalate co-treated with diisononyl phthalate] results in increased expression of ESR1 protein; [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with diisononyl phthalate co-treated with di-n-octyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate] results in increased expression of ESR1 protein; [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of ESR1 mRNAPMID:28013214 PMID:35739755 PMID:37364641
ESR1multiple interactionsISOEsr1 (Rattus norvegicus)6480464CTDDibutyl Phthalate results in increased expression of and affects the localization of ESR1 proteinPMID:36308879
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