GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | ESR1 | affects binding | EXP | | 6480464 | CTD | 4-tert-octylphenol binds to ESR1 protein | PMID:10964929 PMID:11162928 PMID:12161000 PMID:19913605 | ESR1 | increases activity | EXP | | 6480464 | CTD | 4-tert-octylphenol results in increased activity of ESR1 protein mutant form | PMID:17141713 | ESR1 | increases expression | EXP | | 6480464 | CTD | 4-tert-octylphenol results in increased expression of ESR1 mRNA | PMID:12737316 | ESR1 | multiple interactions | EXP | | 6480464 | CTD | 4-tert-octylphenol binds to and results in increased activity of ESR1 protein; 4-tert-octylphenol inhibits the reaction [Estradiol binds to ESR1 protein]; 4-tert-octylphenol promotes the reaction [ESR1 protein binds to NCOA1 protein]; 4-tert-octylphenol promotes the reaction [ESR1 protein binds to NCOA2 protein]; ESR1 mutant form inhibits the reaction [4-tert-octylphenol results in increased expression of CCND1 mRNA]; ESR1 mutant form inhibits the reaction [4-tert-octylphenol results in increased expression of CTSB mRNA]; ESR1 mutant form inhibits the reaction [4-tert-octylphenol results in increased expression of CTSD mRNA] | PMID:10964929 PMID:11530281 PMID:19666091 PMID:23219593 PMID:24684733 PMID:25012808 PMID:27633901 PMID:29162470 PMID:33049310 | ESR1 | affects binding | ISO | Esr1 (Mus musculus) | 6480464 | CTD | 4-tert-octylphenol binds to ESR1 protein | PMID:11162928 | ESR1 | affects binding | ISO | Esr1 (Rattus norvegicus) | 6480464 | CTD | 4-tert-octylphenol binds to ESR1 protein | PMID:11086226 | ESR1 | decreases expression | ISO | Esr1 (Mus musculus) | 6480464 | CTD | 4-tert-octylphenol results in decreased expression of ESR1 mRNA; 4-tert-octylphenol results in decreased expression of ESR1 protein | PMID:23557686 PMID:30061528 | ESR1 | increases activity | ISO | Esr1 (Rattus norvegicus) | 6480464 | CTD | 4-tert-octylphenol results in increased activity of ESR1 protein | PMID:11750080 PMID:12504345 | ESR1 | multiple interactions | ISO | Esr1 (Mus musculus) | 6480464 | CTD | 4-tert-octylphenol inhibits the reaction [Fulvestrant results in increased expression of ESR1 mRNA]; Fulvestrant inhibits the reaction [4-tert-octylphenol results in decreased expression of ESR1 mRNA] | PMID:23557686 PMID:30061528 | | ||||||||||||||||||||||
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