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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736517
Species: Mus musculus
RGD Object: Gene
Symbol: Grik2
Name: glutamate receptor, ionotropic, kainate 2 (beta 2)
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Grik2decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of GRIK2 mRNAPMID:32156529
Grik2decreases expressionISOGrik2 (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of GRIK2 mRNAPMID:25181051
Grik2decreases expressionISOGRIK2 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of GRIK2 mRNAPMID:27685785
Grik2decreases methylationISOGRIK2 (Homo sapiens)6480464CTDbisphenol A results in decreased methylation of GRIK2 genePMID:31601247
Grik2increases expressionISOGrik2 (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of GRIK2 mRNAPMID:30816183 PMID:32528016 PMID:34947998
Grik2multiple interactionsISOGrik2 (Rattus norvegicus)6480464CTD[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of GRIK2 mRNA; [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of GRIK2 mRNA; [bisphenol A co-treated with Estradiol] results in increased expression of GRIK2 mRNAPMID:25607892 PMID:26496021
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