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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736507
Species: Mus musculus
RGD Object: Gene
Symbol: Scn8a
Name: sodium channel, voltage-gated, type VIII, alpha
Acc ID: CHEBI:9506
Term: tetrodotoxin
Definition: A quinazoline alkaloid that is a marine toxin isolated from fish such as puffer fish. It has been shown to exhibit potential neutotoxicity due to its ability to block voltage-gated sodium channels.
Chemical ID: MESH:D013779
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Scn8adecreases activityEXP 6480464CTDTetrodotoxin results in decreased activity of SCN8A proteinPMID:17522141
Scn8amultiple interactionsEXP 6480464CTD[Tetrodotoxin results in decreased activity of [SCN8A protein co-treated with SCN9A protein]] which affects the transport of Sodium; Tetrodotoxin affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of SCN8A protein]; Tetrodotoxin inhibits the reaction [SCN8A protein results in increased transport of Sodium]PMID:16020462 PMID:23382806 PMID:24070585
Scn8amultiple interactionsISOScn8a (Rattus norvegicus)6480464CTDTetrodotoxin results in decreased activity of [SCN8A protein binds to SCN1B protein binds to SCN2B protein]PMID:21983428
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