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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736496
Species: Homo sapiens
RGD Object: Gene
Symbol: MAPT
Name: microtubule associated protein tau
Acc ID: CHEBI:45863
Term: paclitaxel
Definition: A tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark.
Chemical ID: MESH:D017239
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MAPTdecreases expressionEXP 6480464CTDPaclitaxel results in decreased expression of MAPT mRNA; Paclitaxel results in decreased expression of MAPT proteinPMID:16930453
MAPTmultiple interactionsEXP 6480464CTDMAPT mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]PMID:16896004
MAPTmultiple interactionsISOMapt (Rattus norvegicus)6480464CTDPaclitaxel inhibits the reaction [annonacin affects the localization of MAPT protein]PMID:17634376
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