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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736496
Species: Homo sapiens
RGD Object: Gene
Symbol: MAPT
Name: microtubule associated protein tau
Acc ID: CHEBI:28112
Term: nickel atom
Definition: Chemical element (nickel group element atom) with atomic number 28.
Chemical ID: MESH:D009532
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MAPTdecreases expressionEXP 6480464CTDNickel results in decreased expression of MAPT mRNAPMID:24768652 PMID:25583101
MAPTincreases response to substanceEXP 6480464CTDMAPT protein mutant form results in increased susceptibility to NickelPMID:31953414
MAPTmultiple interactionsEXP 6480464CTDNickel results in increased expression of and results in increased phosphorylation of MAPT proteinPMID:31953414
MAPTdecreases expressionISOMapt (Mus musculus)6480464CTDNickel results in decreased expression of MAPT mRNAPMID:12540486
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