GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CCNE1 | decreases expression | EXP | | 6480464 | CTD | Doxorubicin results in decreased expression of CCNE1 protein | PMID:16036217 | CCNE1 | increases expression | EXP | | 6480464 | CTD | Doxorubicin results in increased expression of CCNE1 mRNA; Doxorubicin results in increased expression of CCNE1 protein | PMID:25124555 | CCNE1 | multiple interactions | EXP | | 6480464 | CTD | Doxorubicin inhibits the reaction [HDAC2 protein binds to CCNE1 promoter]; Doxorubicin promotes the reaction [E2F1 protein binds to CCNE1 promoter]; E2F1 protein promotes the reaction [Doxorubicin results in increased expression of CCNE1 protein]; SETD7 protein promotes the reaction [Doxorubicin inhibits the reaction [HDAC2 protein binds to CCNE1 promoter]]; SETD7 protein promotes the reaction [Doxorubicin promotes the reaction [E2F1 protein binds to CCNE1 promoter]]; SETD7 protein promotes the reaction [Doxorubicin results in increased expression of CCNE1 mRNA]; SETD7 protein promotes the reaction [Doxorubicin results in increased expression of CCNE1 protein] | PMID:25124555 | CCNE1 | multiple interactions | ISO | Ccne1 (Rattus norvegicus) | 6480464 | CTD | Doxorubicin promotes the reaction [TAF1 protein results in increased expression of CCNE1 protein] | PMID:15124910 | CCNE1 | multiple interactions | ISO | Ccne1 (Mus musculus) | 6480464 | CTD | [zoledronic acid co-treated with Doxorubicin] results in decreased expression of CCNE1 protein | PMID:19789217 | | ||||||||||||||||||||||
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