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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736474
Species: Homo sapiens
RGD Object: Gene
Symbol: G6PD
Name: glucose-6-phosphate dehydrogenase
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
G6PDaffects expressionISOG6pdx (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of G6PDX mRNAPMID:21570461 PMID:28922406
G6PDaffects expressionISOG6pd (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin affects the expression of G6PD mRNAPMID:22298810
G6PDdecreases expressionISOG6pdx (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of G6PD protein; Tetrachlorodibenzodioxin results in decreased expression of G6PDX mRNAPMID:21354282 PMID:29935226
G6PDincreases expressionISOG6pdx (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of G6PDX mRNAPMID:16960034
G6PDincreases expressionISOG6pd (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased expression of G6PD mRNA; Tetrachlorodibenzodioxin results in increased expression of G6PDX mRNAPMID:16054898 PMID:16466705 PMID:16960034 PMID:20959002 PMID:21215274
G6PDmultiple interactionsISOG6pdx (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of G6PDX mRNA; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to G6PDX promoter]PMID:17942748 PMID:19654925
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