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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736447
Species: Homo sapiens
RGD Object: Gene
Symbol: HSPA5
Name: heat shock protein family A (Hsp70) member 5
Acc ID: CHEBI:29699
Term: tunicamycin
Definition: A mixture of antiviral nucleoside antibiotics produced by Streptomyces lysosuperificus. It contains at least 10 homologues comprising uracil, N-acetylglucosamine, an 11-carbon aminodialdose called tunicamine, and a fatty acid linked to the amino group of the tunicamine. The homologues vary in the composition of the fatty acid moiety.
Chemical ID: MESH:D014415
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HSPA5increases expression ISOHspa5 (Mus musculus)401842386RGDtunicamycin increases expression of Hspa5 mRNA in liver 
HSPA5multiple interactionsISOHspa5 (Mus musculus)401842386RGDnaltrexone inhibits the reaction [tunicamycin increases expression of Hspa5 mRNA in liver] 
HSPA5increases expressionEXP 6480464CTDTunicamycin results in increased expression of HSPA5 mRNA; Tunicamycin results in increased expression of HSPA5 proteinPMID:12147617 PMID:15049342 PMID:16357177 PMID:17416481 PMID:19139269 PMID:19383982 PMID:19428936 PMID:19735704 PMID:20196124 PMID:20593179 PMID:20626587 PMID:21320468 PMID:22378314 PMID:22959463 PMID:23544152 PMID:24210820 PMID:24312631 PMID:27358234 PMID:27588471 PMID:28688763 PMID:29027487 PMID:29453283 PMID:29723631 PMID:30592132 PMID:32357311 PMID:32407927 PMID:32535746 PMID:33545341 PMID:36586010 PMID:36640941
HSPA5multiple interactionsEXP 6480464CTDBortezomib inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]; Curcumin inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]; ERGIC3 protein inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]; Luteolin inhibits the reaction [Tunicamycin results in increased expression of HSPA5 mRNA]; MT2A protein inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]; Quercetin inhibits the reaction [Tunicamycin results in increased expression of HSPA5 mRNA]; Quercetin inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]; SIRT7 protein inhibits the reaction [Tunicamycin results in increased expression of HSPA5 mRNA]; Tunicamycin promotes the reaction [HSPA5 protein binds to CDH13 protein]; ursodoxicoltaurine inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]PMID:16357177 PMID:19428936 PMID:23544152 PMID:24210820 PMID:24680926 PMID:27588471 PMID:29027487 PMID:32407927 PMID:36640941
HSPA5increases expressionISOHspa5 (Mus musculus)6480464CTDTunicamycin results in increased expression of HSPA5 mRNA; Tunicamycin results in increased expression of HSPA5 proteinPMID:15019097 PMID:18799549 PMID:19336499 PMID:20015086 PMID:20477944 PMID:21321189 PMID:22001960 PMID:22509299 PMID:25160872 PMID:25324550 PMID:28698385 PMID:29380555 PMID:29894845 PMID:30253173 PMID:32407927 PMID:32740777 PMID:35341795 PMID:36030031
HSPA5increases expressionISOHspa5 (Rattus norvegicus)6480464CTDTunicamycin results in increased expression of HSPA5 mRNA; Tunicamycin results in increased expression of HSPA5 proteinPMID:15049342 PMID:17416481 PMID:18477628 PMID:20071420 PMID:24291486 PMID:24680926 PMID:24892553 PMID:28399139 PMID:28844859 PMID:29027487 PMID:32574669
HSPA5multiple interactionsISOHspa5 (Mus musculus)6480464CTD3-N-1(spermine)-7, 24-dihydroxy-5-cholestane 24-sulfate inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]; [ATG5 protein mutant form results in increased susceptibility to Tunicamycin] which results in increased expression of HSPA5 mRNA; [Resveratrol results in decreased activity of MTOR protein] inhibits the reaction [Tunicamycin results in increased expression of HSPA5 mRNA]; [Tunicamycin co-treated with HRAS protein] results in increased expression of HSPA5 protein; Amiloride inhibits the reaction [Tunicamycin results in increased expression of HSPA5 mRNA]; Amiloride inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]; Exenatide inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]; HSPA5 protein affects the reaction [[Tunicamycin co-treated with HRAS protein] results in increased phosphorylation of AKT1 protein]; HSPA5 protein affects the reaction [[Tunicamycin co-treated with HRAS protein] results in increased phosphorylation of RB1 protein]; Luteolin inhibits the reaction [Tunicamycin results in increased expression of HSPA5 mRNA]; Luteolin inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]; PTPN1 gene mutant form promotes the reaction [Tunicamycin results in increased expression of HSPA5 protein]; Tunicamycin promotes the reaction [PTPN1 protein binds to HSPA5 protein]PMID:20015086 PMID:21321189 PMID:22509299 PMID:24898257 PMID:29793971 PMID:29894845 PMID:30253173 PMID:32407927
HSPA5multiple interactionsISOHspa5 (Rattus norvegicus)6480464CTD4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of HSPA5 mRNA]; Guanabenz inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]; GW 506033X inhibits the reaction [Tunicamycin results in increased expression of HSPA5 mRNA]; ibutilide inhibits the reaction [Tunicamycin results in increased expression of HSPA5 mRNA]; Nicotine inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]; salubrinal inhibits the reaction [Tunicamycin results in increased expression of HSPA5 mRNA]; ursodoxicoltaurine inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]PMID:18477628 PMID:24892553 PMID:28399139 PMID:28844859 PMID:29027487 PMID:32574669
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