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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736447
Species: Homo sapiens
RGD Object: Gene
Symbol: HSPA5
Name: heat shock protein family A (Hsp70) member 5
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HSPA5decreases expressionEXP 6480464CTDEstradiol results in decreased expression of HSPA5 mRNAPMID:23094148
HSPA5multiple interactionsEXP 6480464CTD[Estradiol co-treated with ESR1 protein] results in increased expression of HSPA5 protein; [Estradiol co-treated with TGFB1 protein] results in increased expression of HSPA5 mRNA; IGF1R mutant form inhibits the reaction [Estradiol results in decreased expression of HSPA5 mRNA]PMID:19269315 PMID:23094148 PMID:30165855
HSPA5increases expressionISOHspa5 (Mus musculus)6480464CTDEstradiol results in increased expression of HSPA5 mRNA; Estradiol results in increased expression of HSPA5 proteinPMID:14664709 PMID:17640991
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