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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736306
Species: Homo sapiens
RGD Object: Gene
Symbol: IL4
Name: interleukin 4
Acc ID: CHEBI:641
Term: N-methyl-4-phenylpyridinium
Definition: A pyridinium ion that is N-methylpyridinium having a phenyl substituent at the 4-position.
Chemical ID: MESH:D015655
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL4multiple interactionsISOIl4 (Mus musculus)6480464CTD1-Methyl-4-phenylpyridinium affects the reaction [IL4 protein results in increased expression of ARG1 mRNA]; 1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of ARG1 mRNA]; 1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of ARG1 protein]; 1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of CD200R1 mRNA]; 1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of CHIL3 mRNA]; 1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of CHIL3 protein]; 1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of FIZ1 mRNA]; 1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of FIZ1 protein]; 1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of IL10]; 1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of IL13]; 1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of MRC1 mRNA]; 1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of MRC1 protein]; 1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of RETNLA mRNA]; 1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of TGFB2]; 1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased phosphorylation of STAT6 protein]; 1-Methyl-4-phenylpyridinium promotes the reaction [IL4 protein results in increased expression of SLC2A1 mRNA]; [IL4 protein co-treated with 1-Methyl-4-phenylpyridinium] affects the expression of TGFB1 mRNA; [IL4 protein co-treated with 1-Methyl-4-phenylpyridinium] results in decreased expression of CD200 mRNA alternative form; [IL4 protein co-treated with 1-Methyl-4-phenylpyridinium] results in decreased expression of IL10 mRNA; [IL4 protein co-treated with 1-Methyl-4-phenylpyridinium] results in decreased expression of SHPK mRNA; [IL4 protein co-treated with 1-Methyl-4-phenylpyridinium] results in increased expression of PFKP mRNA; [IL4 protein co-treated with 1-Methyl-4-phenylpyridinium] results in increased expression of PPARGC1B mRNA; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of ARG1 mRNA]]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of ARG1 protein]]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of CHIL3 mRNA]]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of CHIL3 protein]]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of FIZ1 mRNA]]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of FIZ1 protein]]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of IL10]]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of IL13]]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of TGFB2]]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased phosphorylation of STAT6 protein]]; IL4 protein promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SLC2A1 mRNA]PMID:26114860 PMID:32606391
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