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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736306
Species: Homo sapiens
RGD Object: Gene
Symbol: IL4
Name: interleukin 4
Acc ID: CHEBI:61057
Term: tacrolimus hydrate
Definition: A hydrate that is the monohydrate form of tacrolimus.
Chemical ID: MESH:D016559
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL4decreases expressionEXP 6480464CTDTacrolimus results in decreased expression of IL4 proteinPMID:11407316
IL4multiple interactionsEXP 6480464CTDTacrolimus inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL4 protein]PMID:1371491
IL4decreases expressionISOIl4 (Rattus norvegicus)6480464CTDTacrolimus results in decreased expression of IL4 mRNA; Tacrolimus results in decreased expression of IL4 proteinPMID:10685002 PMID:16368244
IL4multiple interactionsISOIl4 (Mus musculus)6480464CTDTacrolimus inhibits the reaction [bisphenol A promotes the reaction [NFATC3 protein binds to IL4 promoter]]; Tacrolimus inhibits the reaction [bisphenol A results in increased expression of IL4 protein]; Tacrolimus inhibits the reaction [nonylphenol promotes the reaction [NFATC3 protein binds to IL4 promoter]]; Tacrolimus inhibits the reaction [nonylphenol results in increased expression of IL4 protein]PMID:12709020
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