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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736306
Species: Homo sapiens
RGD Object: Gene
Symbol: IL4
Name: interleukin 4
Acc ID: CHEBI:53053
Term: 1-chloro-2,4,6-trinitrobenzene
Definition: The C-nitro compound that is chlorobenzene with three nitro substituents in the 2-, 4- and 6-positions.
Chemical ID: MESH:D010853
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL4increases expressionEXP 6480464CTDPicryl Chloride results in increased expression of IL4 proteinPMID:18854230
IL4multiple interactionsEXP 6480464CTD4-cyano-4-(2,3-dihydro-8-methoxy-1,4-benzodioxin-5-yl)cyclohexanecarboxylic acid inhibits the reaction [Picryl Chloride results in increased expression of IL4 protein]PMID:18854230
IL4increases expressionISOIl4 (Mus musculus)6480464CTDPicryl Chloride results in increased expression of IL4; Picryl Chloride results in increased expression of IL4 mRNA; Picryl Chloride results in increased expression of IL4 proteinPMID:12188032 PMID:15734285 PMID:16442096 PMID:21804303 PMID:23817207
IL4multiple interactionsISOIl4 (Mus musculus)6480464CTD[Picryl Chloride co-treated with pirinixic acid] results in decreased expression of IL4 protein; bu-zhong-yi-qi-tang inhibits the reaction [Picryl Chloride results in increased expression of IL4 protein]; Cyclosporine inhibits the reaction [Picryl Chloride results in increased expression of IL4 protein]; Dexamethasone inhibits the reaction [Picryl Chloride results in increased expression of IL4 mRNA]; Particulate Matter analog promotes the reaction [Picryl Chloride results in increased expression of IL4]; PPARA protein affects the reaction [[Picryl Chloride co-treated with pirinixic acid] results in decreased expression of IL4 protein]; Prednisolone inhibits the reaction [Picryl Chloride results in increased expression of IL4 protein]; Rolipram inhibits the reaction [Picryl Chloride results in increased expression of IL4 protein]; Vehicle Emissions analog promotes the reaction [Picryl Chloride results in increased expression of IL4]PMID:12188032 PMID:16442096 PMID:17371993 PMID:21804303 PMID:23817207
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