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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736306
Species: Homo sapiens
RGD Object: Gene
Symbol: IL4
Name: interleukin 4
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL4decreases expressionEXP 6480464CTDDexamethasone results in decreased expression of IL4 mRNA; Dexamethasone results in decreased expression of IL4 proteinPMID:10596698 PMID:18357729
IL4decreases secretionEXP 6480464CTDDexamethasone results in decreased secretion of IL4 proteinPMID:16321374
IL4multiple interactionsEXP 6480464CTD[Dexamethasone co-treated with IL4 protein] results in increased expression of CHID1 mRNA; [Dexamethasone co-treated with IL4 protein] results in increased expression of CHID1 protein; [IL4 protein co-treated with IL2 protein] results in decreased susceptibility to Dexamethasone; ABCB1 gene polymorphism affects the reaction [Dexamethasone results in decreased secretion of IL4 protein]; Dexamethasone inhibits the reaction [IL4 protein results in increased expression of CCL26 protein]; Dexamethasone inhibits the reaction [IL4 protein results in increased secretion of CSF2 protein]; Dexamethasone inhibits the reaction [IL4 protein results in increased secretion of CXCL8 protein]; IFNG protein inhibits the reaction [[Dexamethasone co-treated with IL4 protein] results in increased expression of CHID1 mRNA]PMID:12077271 PMID:16045735 PMID:16321374 PMID:16357325 PMID:22205926
IL4decreases expressionISOIl4 (Mus musculus)6480464CTDDexamethasone results in decreased expression of IL4 proteinPMID:7988651
IL4increases expressionISOIl4 (Mus musculus)6480464CTDDexamethasone results in increased expression of IL4 mRNA; Dexamethasone results in increased expression of IL4 proteinPMID:22842586
IL4multiple interactionsISOIl4 (Mus musculus)6480464CTDDexamethasone inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of IL4 protein]; Dexamethasone inhibits the reaction [Antigens, Dermatophagoides results in increased expression of IL4 mRNA]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of IL4 protein]; Dexamethasone inhibits the reaction [Ovalbumin results in increased expression of IL4 protein]; Dexamethasone inhibits the reaction [Ovalbumin results in increased secretion of IL4 protein]; Dexamethasone inhibits the reaction [ovalbumin-alum results in increased expression of IL4 mRNA]; Dexamethasone inhibits the reaction [Picryl Chloride results in increased expression of IL4 mRNA]PMID:21804303 PMID:27568862 PMID:27884791 PMID:31669322 PMID:31751647 PMID:35481609 PMID:36350155
IL4multiple interactionsISOIl4 (Rattus norvegicus)6480464CTDDexamethasone inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased expression of IL4 mRNA]; Dexamethasone inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL4 mRNA]; Dexamethasone inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL4 protein]PMID:16867261 PMID:31751647
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