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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736306
Species: Homo sapiens
RGD Object: Gene
Symbol: IL4
Name: interleukin 4
Acc ID: CHEBI:16842
Term: formaldehyde
Definition: An aldehyde resulting from the formal oxidation of methanol.
Chemical ID: MESH:D005557
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL4affects expressionISOIl4 (Mus musculus)6480464CTDFormaldehyde affects the expression of IL4 proteinPMID:19422874
IL4increases expressionISOIl4 (Mus musculus)6480464CTDFormaldehyde results in increased expression of IL4 mRNA; Formaldehyde results in increased expression of IL4 proteinPMID:12161283 PMID:19042193 PMID:19904815
IL4increases expressionISOIl4 (Rattus norvegicus)6480464CTDFormaldehyde results in increased expression of IL4 mRNA; Formaldehyde results in increased expression of IL4 proteinPMID:19827972 PMID:28005965
IL4multiple interactionsISOIl4 (Mus musculus)6480464CTD2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [[Ovalbumin co-treated with Formaldehyde] results in increased expression of and results in increased secretion of IL4 protein]; [Formaldehyde co-treated with diisononyl phthalate] promotes the reaction [OVAL protein results in increased secretion of IL4 protein]; [Ovalbumin co-treated with Formaldehyde] results in increased expression of and results in increased secretion of IL4 protein; capsazepine inhibits the reaction [[Ovalbumin co-treated with Formaldehyde] results in increased expression of and results in increased secretion of IL4 protein]PMID:23671638 PMID:29758289
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