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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736289
Species: Homo sapiens
RGD Object: Gene
Symbol: PPARD
Name: peroxisome proliferator activated receptor delta
Acc ID: CHEBI:32509
Term: pirinixic acid
Definition: An aryl sulfide that has formula C14H14ClN3O2S.
Chemical ID: MESH:C006253
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PPARDincreases activityEXP 6480464CTDpirinixic acid results in increased activity of PPARD proteinPMID:26135921 PMID:9703482
PPARDincreases expressionEXP 6480464CTDpirinixic acid results in increased expression of PPARD mRNAPMID:19667161
PPARDmultiple interactionsEXP 6480464CTD[Calcitriol co-treated with pirinixic acid] results in increased expression of PPARD mRNA; [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PPARD mRNAPMID:19667161 PMID:19710929
PPARDmultiple interactionsISOPpard (Mus musculus)6480464CTD[pirinixic acid results in increased activity of PPARD protein] which results in increased expression of NFKBIA mRNA; pirinixic acid promotes the reaction [PPARD protein binds to NFKBIA promoter]; pirinixic acid results in increased activity of [PPARD protein co-treated with RXRA protein]PMID:19438714 PMID:8700121
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