Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736204
Species: Homo sapiens
RGD Object: Gene
Symbol: IRS2
Name: insulin receptor substrate 2
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IRS2increases expressionEXP 6480464CTDProgesterone results in increased expression of IRS2 mRNA; Progesterone results in increased expression of IRS2 proteinPMID:15949379 PMID:17404688 PMID:20864642 PMID:21795739
IRS2increases phosphorylationEXP 6480464CTDProgesterone results in increased phosphorylation of IRS2 proteinPMID:15949379
IRS2multiple interactionsEXP 6480464CTD[Progesterone co-treated with Estradiol] results in increased expression of IRS2 mRNA; Estradiol promotes the reaction [Progesterone results in increased expression of IRS2 mRNA]; Estradiol promotes the reaction [Progesterone results in increased expression of IRS2 protein]; Estradiol promotes the reaction [Progesterone results in increased phosphorylation of IRS2 protein]PMID:15949379 PMID:17404688
Go Back to source page   Continue to Ontology report