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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736187
Species: Homo sapiens
RGD Object: Gene
Symbol: PRL
Name: prolactin
Acc ID: CHEBI:64211
Term: 8-Br-cAMP
Definition: A 3',5'-cyclic purine nucleotide that is 3',5'-cyclic AMP bearing an additional bromo substituent at position 8 on the adenine ring. An activator of cyclic AMP-dependent protein kinase, but resistant to degradation by cyclic AMP phosphodiesterase.
Chemical ID: MESH:D015124
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PRLdecreases expressionEXP 6480464CTD8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of PRL mRNA; 8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of PRL proteinPMID:18815356
PRLincreases expressionEXP 6480464CTD8-Bromo Cyclic Adenosine Monophosphate results in increased expression of PRL mRNA; 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of PRL proteinPMID:15774544 PMID:17065600 PMID:20147733 PMID:20955787 PMID:23275455
PRLincreases secretionEXP 6480464CTD8-Bromo Cyclic Adenosine Monophosphate results in increased secretion of PRL proteinPMID:21273127
PRLmultiple interactionsEXP 6480464CTD1-Butanol inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of PRL mRNA]; [8-Bromo Cyclic Adenosine Monophosphate co-treated with Dexamethasone] results in increased expression of PRL mRNA; [8-Bromo Cyclic Adenosine Monophosphate co-treated with Medroxyprogesterone Acetate] results in increased expression of PRL mRNA; [Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased secretion of PRL protein; EZH2 mutant form inhibits the reaction [[8-Bromo Cyclic Adenosine Monophosphate co-treated with Medroxyprogesterone Acetate] results in increased expression of PRL mRNA]; FOXO1 protein affects the reaction [[Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased secretion of PRL protein]; PLD1 protein affects the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of PRL mRNA]; Progesterone promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of PRL mRNA]; Tobacco Smoke Pollution inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of PRL mRNA]PMID:16709600 PMID:17065600 PMID:20955787 PMID:21903722 PMID:23275455
PRLincreases expressionISOPrl (Rattus norvegicus)6480464CTD8-Bromo Cyclic Adenosine Monophosphate results in increased expression of PRL mRNAPMID:21467749
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