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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736187
Species: Homo sapiens
RGD Object: Gene
Symbol: PRL
Name: prolactin
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PRLaffects expressionISOPrl (Rattus norvegicus)6480464CTDCadmium Chloride affects the expression of PRL mRNA; Cadmium Chloride affects the expression of PRL proteinPMID:23085516
PRLdecreases expressionISOPrl (Rattus norvegicus)6480464CTDCadmium Chloride results in decreased expression of PRL mRNAPMID:19894126
PRLincreases expressionISOPrl (Rattus norvegicus)6480464CTDCadmium Chloride results in increased expression of PRL mRNAPMID:24236210
PRLmultiple interactionsISOPrl (Rattus norvegicus)6480464CTDCadmium Chloride results in increased expression of and results in increased secretion of PRL protein; fulvestrant inhibits the reaction [Cadmium Chloride results in increased expression of PRL mRNA]; Melatonin inhibits the reaction [Cadmium Chloride affects the expression of PRL mRNA]; Melatonin inhibits the reaction [Cadmium Chloride affects the expression of PRL protein]; Melatonin inhibits the reaction [Cadmium Chloride affects the expression of PRL]PMID:23085516 PMID:24236210
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