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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736173
Species: Mus musculus
RGD Object: Gene
Symbol: Becn1
Name: beclin 1, autophagy related
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Becn1increases expressionEXP 6480464CTDArsenic Trioxide results in increased expression of BECN1 mRNA; Arsenic Trioxide results in increased expression of BECN1 proteinPMID:30032600 PMID:30225639 PMID:31149761 PMID:32112876 PMID:32781346 PMID:33462182
Becn1multiple interactionsEXP 6480464CTD3-methyladenine inhibits the reaction [Arsenic Trioxide results in increased expression of BECN1 mRNA]; [Cisplatin co-treated with Arsenic Trioxide] results in increased expression of BECN1 proteinPMID:31149761 PMID:33462182
Becn1decreases expressionISOBecn1 (Rattus norvegicus)6480464CTDArsenic Trioxide results in decreased expression of BECN1 proteinPMID:35195477
Becn1increases expressionISOBECN1 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of BECN1; Arsenic Trioxide results in increased expression of BECN1 mRNA; Arsenic Trioxide results in increased expression of BECN1 proteinPMID:16882451 PMID:20200477 PMID:21594580 PMID:22519831 PMID:25110043
Becn1multiple interactionsISOBecn1 (Rattus norvegicus)6480464CTDferrostatin-1 inhibits the reaction [Arsenic Trioxide results in decreased expression of BECN1 protein]PMID:35195477
Becn1multiple interactionsISOBECN1 (Homo sapiens)6480464CTD3-methyladenine inhibits the reaction [Arsenic Trioxide results in increased expression of BECN1]; Arsenic Trioxide promotes the reaction [ABL1 protein mutant form binds to BECN1 protein]; BECN1 protein promotes the reaction [Arsenic Trioxide results in increased degradation of BCR protein mutant form]; Cycloheximide inhibits the reaction [Arsenic Trioxide results in increased expression of BECN1 protein]PMID:16882451 PMID:22898604 PMID:25110043 PMID:33070465
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