GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Becn1 | affects splicing | EXP | | 6480464 | CTD | Ethanol affects the splicing of BECN1 mRNA | PMID:30319688 | Becn1 | decreases expression | EXP | | 6480464 | CTD | Ethanol results in decreased expression of BECN1 protein | PMID:34405320 | Becn1 | increases expression | EXP | | 6480464 | CTD | Ethanol results in increased expression of BECN1 mRNA; Ethanol results in increased expression of BECN1 protein | PMID:24095927 PMID:24492484 PMID:25460735 PMID:28419832 PMID:29524503 | Becn1 | multiple interactions | EXP | | 6480464 | CTD | Dactinomycin inhibits the reaction [Ethanol results in increased expression of BECN1 protein]; dihydromyricetin promotes the reaction [Ethanol results in increased expression of BECN1 protein]; Ethanol promotes the reaction [Mirtazapine results in increased expression of BECN1 protein]; FOXO3 protein affects the reaction [Ethanol results in increased expression of BECN1 mRNA]; FOXO3 protein affects the reaction [Ethanol results in increased expression of BECN1 protein]; NR1H4 gene mutant form inhibits the reaction [Ethanol results in increased expression of BECN1 mRNA]; pterostilbene inhibits the reaction [Ethanol results in decreased expression of BECN1 protein]; SESN2 protein promotes the reaction [pterostilbene inhibits the reaction [Ethanol results in decreased expression of BECN1 protein]] | PMID:24095927 PMID:25460735 PMID:28419832 PMID:34405320 PMID:35066094 | Becn1 | decreases expression | ISO | BECN1 (Homo sapiens) | 6480464 | CTD | Ethanol results in decreased expression of BECN1 protein | PMID:21410490 PMID:34405320 | Becn1 | increases degradation | ISO | BECN1 (Homo sapiens) | 6480464 | CTD | Ethanol results in increased degradation of BECN1 protein | PMID:21410490 | Becn1 | increases expression | ISO | BECN1 (Homo sapiens) | 6480464 | CTD | Ethanol results in increased expression of BECN1 mRNA | PMID:24095927 | Becn1 | multiple interactions | ISO | Becn1 (Rattus norvegicus) | 6480464 | CTD | 3-methyladenine inhibits the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of BECN1 protein]]; Ethanol promotes the reaction [Mirtazapine results in increased expression of BECN1 protein]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of BECN1 protein]] | PMID:35066094 | Becn1 | multiple interactions | ISO | BECN1 (Homo sapiens) | 6480464 | CTD | BECN1 protein promotes the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of CCN1 protein]]; pterostilbene inhibits the reaction [Ethanol results in decreased expression of BECN1 protein]; SESN2 protein promotes the reaction [pterostilbene inhibits the reaction [Ethanol results in decreased expression of BECN1 protein]]; Sirolimus inhibits the reaction [Ethanol results in increased degradation of BECN1 protein]; Wortmannin promotes the reaction [Ethanol results in increased degradation of BECN1 protein] | PMID:21410490 PMID:34405320 | | ||||||||||||||||||||||
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