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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736060
Species: Homo sapiens
RGD Object: Gene
Symbol: GSTM1
Name: glutathione S-transferase mu 1
Acc ID: CHEBI:76359
Term: butylated hydroxyanisole
Definition: A mixture of 2-tert-butyl-4-hydroxyanisole and 3-tert-butyl-4-hydroxyanisole. Is is used as an antioxidant and preservative in food, cosmetics, pharmaceuticals, rubber and petroleum products.
Chemical ID: MESH:D002083
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GSTM1increases activityISOGstm1 (Mus musculus)6480464CTDButylated Hydroxyanisole results in increased activity of GSTM1 proteinPMID:11895860
GSTM1increases expressionISOGstm1 (Mus musculus)6480464CTDButylated Hydroxyanisole results in increased expression of GSTM1 mRNA; Butylated Hydroxyanisole results in increased expression of GSTM1 protein; Butylated Hydroxyanisole results in increased expression of GSTM5 proteinPMID:11309284 PMID:11991805 PMID:18723825 PMID:2597111 PMID:29086419
GSTM1multiple interactionsISOGstm1 (Mus musculus)6480464CTDNFE2L2 protein affects the reaction [Butylated Hydroxyanisole results in increased activity of GSTM1 protein]PMID:11895860
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