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RGD ID: 736050
Species: Mus musculus
RGD Object: Gene
Symbol: Gpx4
Name: glutathione peroxidase 4
Acc ID: GO:0006979
Term: response to oxidative stress
Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
Definition Source(s): GOC:jl, PMID:12115731
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 IMP 2290270UniProtKB (MGI:MGI:5615528, PMID:25402683), (MGI:MGI:6114953, PMID:29290465)

MGI:MGI:5615528, MGI:MGI:6114953, PMID:25402683, PMID:29290465
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.