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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736050
Species: Mus musculus
RGD Object: Gene
Symbol: Gpx4
Name: glutathione peroxidase 4
Acc ID: CHEBI:27568
Term: selenium atom
Definition: A chalcogen that has formula Se.
Chemical ID: MESH:D012643
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases abundanceEXP 6480464CTDGPX4 gene mutant form results in decreased abundance of Selenium

PMID:16246897
affects activityISORGD:692266480464CTDSelenium affects the activity of GPX4 protein

PMID:19106321
decreases activityISORGD:692266480464CTDSelenium deficiency results in decreased activity of GPX4 protein

PMID:12031252
decreases expressionISORGD:692266480464CTDSelenium deficiency results in decreased expression of GPX4 mRNA

PMID:12031252, PMID:15670848, PMID:15792362
decreases expressionISORGD:7360496480464CTDSelenium deficiency results in decreased expression of GPX4 mRNA

PMID:15670848
increases activityISORGD:692266480464CTDSelenium results in increased activity of GPX4 protein

PMID:19022953
increases activityISORGD:7360496480464CTDSelenium analog results in increased activity of GPX4 protein

PMID:11673642
increases expressionISORGD:692266480464CTDSelenium results in increased expression of GPX4 mRNA

PMID:15792362, PMID:19022953
increases expressionISORGD:7360496480464CTDSelenium results in increased expression of GPX4 mRNA, Selenium results in increased expression of GPX4 protein

PMID:17052796, PMID:19244175
multiple interactionsISORGD:7360496480464CTDSelenium results in increased expression of and results in increased activity of GPX4 protein

PMID:17150329
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.