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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736047
Species: Mus musculus
RGD Object: Gene
Symbol: Notch2
Name: notch 2
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Notch2increases expressionEXP 6480464CTDbisphenol A results in increased expression of NOTCH2 mRNAPMID:35598803
Notch2affects expressionISONotch2 (Rattus norvegicus)6480464CTDbisphenol A affects the expression of NOTCH2 mRNAPMID:32145629
Notch2affects expressionISONOTCH2 (Homo sapiens)6480464CTDbisphenol A affects the expression of NOTCH2 proteinPMID:34186270
Notch2decreases expressionISONotch2 (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of NOTCH2 mRNAPMID:25181051 PMID:30816183
Notch2increases expressionISONotch2 (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of NOTCH2 mRNAPMID:34858468
Notch2increases methylationISONotch2 (Rattus norvegicus)6480464CTDbisphenol A results in increased methylation of NOTCH2 genePMID:28505145
Notch2multiple interactionsISONotch2 (Rattus norvegicus)6480464CTD[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of NOTCH2 promoter; [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of NOTCH2 mRNA; [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of NOTCH2 mRNAPMID:23359474 PMID:25607892
Notch2multiple interactionsISONOTCH2 (Homo sapiens)6480464CTDbisphenol A promotes the reaction [NOTCH2 protein binds to ESR1 protein]PMID:27156127
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