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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736042
Species: Homo sapiens
RGD Object: Gene
Symbol: IGFBP3
Name: insulin like growth factor binding protein 3
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IGFBP3decreases expressionEXP 6480464CTDEstradiol results in decreased expression of IGFBP3 mRNA; Estradiol results in decreased expression of IGFBP3 proteinPMID:10843175 PMID:15855258 PMID:23019147 PMID:25321415 PMID:31923581 PMID:36828454
IGFBP3decreases secretionEXP 6480464CTDEstradiol results in decreased secretion of IGFBP3 proteinPMID:15809018
IGFBP3increases expressionEXP 6480464CTDEstradiol results in increased expression of IGFBP3 mRNAPMID:12154049 PMID:19619570 PMID:20106945
IGFBP3multiple interactionsEXP 6480464CTD[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of IGFBP3 mRNA; [Estradiol co-treated with Progesterone] results in decreased expression of IGFBP3 mRNA; [Estradiol co-treated with Progesterone] results in decreased secretion of IGFBP3 protein; [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of IGFBP3 mRNA; [Estradiol co-treated with TGFB1 protein] results in increased expression of IGFBP3 mRNA; [Progesterone co-treated with Estradiol] results in decreased expression of IGFBP3 mRNAPMID:15809018 PMID:17404688 PMID:19619570 PMID:20660070 PMID:20823114 PMID:30165855
IGFBP3decreases expressionISOIgfbp3 (Mus musculus)6480464CTDEstradiol results in decreased expression of IGFBP3 mRNAPMID:19341330 PMID:25210133
IGFBP3decreases expressionISOIgfbp3 (Rattus norvegicus)6480464CTDEstradiol results in decreased expression of IGFBP3 mRNAPMID:32145629
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