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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736024
Species: Mus musculus
RGD Object: Gene
Symbol: Mapk9
Name: mitogen-activated protein kinase 9
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk9decreases expressionISOMAPK9 (Homo sapiens)6480464CTDDoxorubicin results in decreased expression of MAPK9 mRNAPMID:29803840
Mapk9increases phosphorylationISOMapk9 (Rattus norvegicus)6480464CTDDoxorubicin results in increased phosphorylation of MAPK9 proteinPMID:16213474 PMID:17384285 PMID:26335259 PMID:35843304
Mapk9increases phosphorylationISOMAPK9 (Homo sapiens)6480464CTDDoxorubicin results in increased phosphorylation of MAPK9 proteinPMID:15557793 PMID:15585644 PMID:31563593
Mapk9multiple interactionsISOMapk9 (Rattus norvegicus)6480464CTD[Taurine binds to Zinc] inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK9 protein]; Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK9 protein; galangin inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK9 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK9 protein]; Taurine inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK9 protein]PMID:16687611 PMID:26335259 PMID:35843304
Mapk9multiple interactionsISOMAPK9 (Homo sapiens)6480464CTD4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK9 protein]; [Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of MAPK9 protein; Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK9 protein; pyrrolidine dithiocarbamic acid inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK9 protein]; RBL2 protein inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK9 protein]PMID:15494689 PMID:15557793 PMID:15585644 PMID:21214929
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