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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736021
Species: Homo sapiens
RGD Object: Gene
Symbol: APP
Name: amyloid beta precursor protein
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
APPmultiple interactionsEXP 6480464CTD[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP mRNA; [Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP protein; [NAT10 protein affects the susceptibility to Lipopolysaccharides] which affects the expression of APP mRNA; Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP mRNA]; Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP protein]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP mRNA]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP protein]PMID:28242320 PMID:35877022
APPincreases expressionISOApp (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of APP mRNAPMID:15919760
APPmultiple interactionsISOApp (Rattus norvegicus)6480464CTDAPP protein modified form inhibits the reaction [Lipopolysaccharides results in increased activity of CEBPD protein]; APP protein modified form inhibits the reaction [Lipopolysaccharides results in increased expression of CEBPD protein]; APP protein modified form promotes the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of NOS2 protein]; Vitamin E inhibits the reaction [APP protein modified form promotes the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of NOS2 protein]]PMID:15223066 PMID:18405661
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