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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736015
Species: Homo sapiens
RGD Object: Gene
Symbol: ACACA
Name: acetyl-CoA carboxylase alpha
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ACACAincreases phosphorylationEXP 6480464CTDresveratrol results in increased phosphorylation of ACACA proteinPMID:18482975 PMID:19071085 PMID:20080969 PMID:21778691 PMID:25943029
ACACAmultiple interactionsEXP 6480464CTD[Plant Extracts co-treated with Resveratrol] results in increased expression of ACACA mRNA; [splitomicin results in decreased activity of SIRT1 protein] inhibits the reaction [Resveratrol results in increased phosphorylation of ACACA protein]; dorsomorphin inhibits the reaction [Resveratrol results in increased phosphorylation of ACACA protein]; Resveratrol inhibits the reaction [T0901317 results in increased expression of ACACA mRNA]; SIRT1 protein promotes the reaction [Resveratrol results in increased phosphorylation of ACACA protein]PMID:18482975 PMID:21778691 PMID:23557933 PMID:23651738
ACACAdecreases expressionISOAcaca (Mus musculus)6480464CTDresveratrol analog results in decreased expression of ACACA protein; resveratrol results in decreased expression of ACACA mRNAPMID:18755807 PMID:24722352 PMID:24779192
ACACAincreases phosphorylationISOAcaca (Mus musculus)6480464CTDresveratrol results in increased phosphorylation of ACACA proteinPMID:17438283 PMID:17464184 PMID:19071085 PMID:20080969
ACACAincreases phosphorylationISOAcaca (Rattus norvegicus)6480464CTDresveratrol results in increased phosphorylation of ACACA proteinPMID:19071085
ACACAmultiple interactionsISOAcaca (Mus musculus)6480464CTD[Resveratrol co-treated with Dietary Fats] results in decreased expression of ACACA mRNA; [T0901317 co-treated with Resveratrol] results in increased phosphorylation of ACACA protein; Resveratrol inhibits the reaction [Ethanol results in increased expression of ACACA mRNA]; Resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of ACACA protein]; STK11 protein promotes the reaction [Resveratrol results in increased phosphorylation of ACACA protein]PMID:17438283 PMID:18755807 PMID:22025971 PMID:23591747 PMID:24985011
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