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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736011
Species: Homo sapiens
RGD Object: Gene
Symbol: G6PC1
Name: glucose-6-phosphatase catalytic subunit 1
Acc ID: CHEBI:42758
Term: aldehydo-D-glucose
Definition: The open chain form of D-glucose.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
G6PC1increases expressionEXP 6480464CTDGlucose results in increased expression of G6PC1 mRNAPMID:36156098
G6PC1multiple interactionsEXP 6480464CTDGlucose promotes the reaction [[ARNT protein binds to G6PC1 promoter] which results in increased expression of G6PC1 mRNA]; Glucose results in increased stability of and results in increased expression of G6PC1 mRNAPMID:15767253
G6PC1decreases expressionISOG6pc1 (Rattus norvegicus)6480464CTDGlucose results in decreased expression of G6PC1 mRNAPMID:14988444
G6PC1increases activityISOG6pc1 (Rattus norvegicus)6480464CTDGlucose results in increased activity of G6PC1 proteinPMID:16920846
G6PC1increases expressionISOG6pc1 (Rattus norvegicus)6480464CTDGlucose results in increased expression of G6PC1 mRNAPMID:19576170 PMID:31974165
G6PC1multiple interactionsISOG6pc1 (Rattus norvegicus)6480464CTDMetformin inhibits the reaction [Glucose results in increased expression of G6PC1 mRNA]; tungstate inhibits the reaction [Glucose results in increased activity of G6PC1 protein]; Vanadates inhibits the reaction [Glucose results in increased activity of G6PC1 protein]PMID:16920846 PMID:19576170 PMID:31974165
G6PC1multiple interactionsISOG6pc1 (Mus musculus)6480464CTD[Glucose co-treated with S 4048] results in increased expression of G6PC1 mRNAPMID:31974165
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